Charles Nicolle (1866-1936).

Charles Nicolle (1866-1936): bacteriologist and conqueror of typhus.

Pulmonary nodules in a patient with rheumatoid arthritis: Which diagnostic approach is the most appropiate?

Background: Pulmonary nodular excavation should firstly evoke tuberculosis or necrosis broncho-pulmonary tumor, particularly: epidermoid carcinoma. The case discussed here illustrated these difficulties in patients with rheumatoid arthritis (RA). Case Presentation: A 63-year-old woman was presented with a-three-year history of RA and a recent discovery of an excavated pulmonary nodule. Initi...

Reparative radiological changes of hip joint after TNF inhibitors in ankylosing spondylitis

Background: Hip involvement in ankylosing spondylitis (AS) is a common extraspinal arthritic manifestation, which is associated to a worse functional outcome. Little data are available on the effectiveness of conservative treatment strategies. The TNF inhibitors have been proven effective on AS activity parameters. Their structural effect on hip disease however, little is studied. Case pres...

Charles-Jules-Henri Nicolle

sia. Nicolle's many accomplishments include the discovery that epidemic typhus is transmitted by body lice (Pediculus humanis corporis), discovery of the phenomenon of inap-parent infection, and possibly the first isolation of human influenza virus after experimental transmission. Nicolle made many other fundamental contributions to knowledge of infectious diseases. This year is the centenary o...

The Nervous Patient: A Frontier of Internal Medicine